Effect of an iris-fixated intraocular lens on corneal metabolism: a numerical study

Peyman Davvalo Khongar, Jan O. Pralits, Xi Cheng, Peter Pinsky, Paolo Soleri, Rodolfo Repetto


One of the possible risks associated with the implant of iris-fixated phakic intraocular lenses (pIOL) is loss of corneal endothelial cells. We hypothesize that this might be due to alterations in corneal metabolism secondary to the lens implantation. To verify the feasibility of this assumption, we propose a mathematical model of the transport and diffusion of metabolic species in the anterior chamber and the cornea, coupled to a model of aqueous flow. Results are obtained both with and without the pIOL in the case of closed eyelids. The results suggest that glucose availability may be significantly reduced at the corneal endothelium. However, it must still be verified whether this finding has clinical relevance.


aqueous flow; corneal metabolism; intraocular lens

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Repetto R, Pralits, JO, Siggers, JH, Soleri P. Phakic iris-fixated intraocular lens placement in the anterior chamber: effects on aqueous flow. Invest Ophthalmol Visual Sci. 2015;56(5):3061–3068.

Chhabra M, Prausnitz JM, Radke CJ. Diffusion and monod kinetics to determine in vivo human corneal oxygen-consumption rate during soft contact-lens wear. J Biomed Mater Res B Appl Biomater. 2009;90(1):202–209.

Pinsky PM. Three-Dimensional modeling of metabolic species transport in the cornea with a hydrogel intrastromal inlay. Invest Ophthalmol Visual Sci. 2014;55(5):3093–3106.

Alvord LA, Hall WJ, Keyes LD, Morgan CF, Winterton LC. Corneal oxygen distribution with contact lens wear. Cornea. 2007;26(6):654–664.

Bonanno JA, Polse KA. Corneal acidosis during contact lens wear: effects of hypoxia and CO2. Invest Ophthalmol Visual Sci. 1987;28(9):1514–1520.


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