Saccadic movement effects on intraocular drug delivery for a wet-AMD clinical case

Marco Ferroni, Matteo Cereda, Federica Boschetti


Nowadays, intravitreal injections are the gold standard for the treatment of age-related macular degeneration (AMD). The prediction of the transport mechanism for the injected anti vascular endothelial growth factor (anti-VEGF) is needed in order to understand its distribution and consumption after each injection. Thus, this study aims at implementing a full model of vitreous drug delivery. The main novelty of this work is the coupling between an experimental evaluation of the scleral permeability and a numerical analysis of the saccadic dependency of the transport phenomena.


age-related macular degeneration (AMD); computational fluid-dynamics; saccade; vitreous drug delivery

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