A proposed mechanism for tear film breakup: a molecular level view by employing in-silico approach

Lukasz Cwiklik, Adela Melcrova, Philippe Daull, Jean-Sebastien Garrigue


dry eye disease, molecular dynamics, molecular simulations, tear film, tear film lipid layer

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Braun RJ. Dynamics of the tear film. Annu Rev Fluid Mech. 2012;44:267-297.

King-Smith PE, Bailey MD, Braun RJ. Four characteristics and a model of an effective tear film lipid layer (TFLL). Ocul Surf. 2013;11:236-245.3.

Yokoi N, Georgiev GA, Kato H, et al. Classification of fluorescein breakup patterns: a novel method of differential diagnosis for dry eye. Am J Ophthalmol. 2017; 180,72-85.

Cwiklik L. Tear film lipid layer: A molecular level view. Biochim Biophys Acta-Biomembranes. 2016;10:2421-2430.

Quentric Y, Daull P, Feraille L, Elena P-P, Garrigue J-S. Efficacy of a preservative-free cationic emulsion vehicle eye drop in a mouse model of dry eye. Invest Ophthalmol Vis Sci. 2016;57:422.

Amrane M, Creuzot-Garcher C, Robert P-Y, et al. Ocular tolerability and efficacy of a cationic emulsion in patients with mild to moderate dry eye disease–A randomised comparative study. J Fr Ophtalmol.


Cwiklik L, Melcrova A, Daull P, Garrigue J-S. Tear film break-up: a molecular level view by employing in silico approach. Invest Ophthalmol Vis Sci. 2017;58:472.

Marrink SJ, Risselada HJ, Yefimov S, Tieleman DP, de Vries AH. The MARTINI force field: coarse grained model for biomolecular simulations. J Phys Chem B. 2007;111:7812-7824.

Wizert A, Iskander DR, Cwiklik L. Organization of lipids in the tear film: a molecular-level view. Plos One. 2014;9,e92461.

Olżyńska A, Cwiklik L. Behavior of sphingomyelin and ceramide in a tear film lipid layer model. Ann Anat. 2017;210:128-134.

Rantamaki AH, Seppanen-Laakso T, Oresic M, Jauhiainen M, Holopainen JM. Human tear fluid lipidome: from composition to function. PLoS One. 2011;6:e19553.


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