Cerebrospinal fluid pressure and glaucoma

Ningli Wang, Diya Yang


Cerebrospinal fluid pressure (CSFP) and glaucoma relationship has aroused great interest in recent years. Before that, Elevated intraocular pressure (IOP) has long being considered as the major risk factors for the development and progression of glaucomatous optic nerve damage [1]. However, numerous studies have shown that a relatively large number of patients with typical glaucomatous optic neuropathy (Normal Tension Glaucoma, NTG), in whom the IOP measurements have always been in the normal range (<21mmHg) [2]. Thus, it was illusive that why do NTG patients develop into glaucoma without high IOP? Are there factors other than IOP contributing to the pathogenesis of NTG? Has IOP becomes vague and controversial as the risk factor for glaucoma?

Full Text:



Leske MC, Heijl A, Hussein M, et al. Factors for glaucoma progression and the effect of treatment: the Early Manifest Glaucoma Trial. Arch Ophthalmol 2003; 121:48-56.

Drance SM. Some factors in the production of low tension glaucoma. Br J Ophthalmol 1972;56:229-42.

Volkov VV. Essential element of the glaucomatous process neglected in clinical practice [in Russian]. Oftalmol Zh 1976;31:500–4.

Yablonski M, Ritch R, Pokorny KS. Effect of decreased intracranial pressure on optic disc. Invest Ophthalmol Vis Sci 1979;18[Suppl]:165.

Berdahl JP, Allingham RR, Johnson DH. Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma. Ophthalmology. 2008;115:763-8.

Berdahl JP, Fautsch MP, Stinnett SS, Allingham RR. Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. Invest Ophthalmol Vis Sci 2008;49:5412-8.

Ren R, Jonas JB, Tian G, et al. Cerebrospinal fluid pressure in glaucoma. A prospective study. Ophthalmology 2010;117:259-66.

Ren R, Zhang X, Wang N, Li B, Tian G, Jonas JB. Cerebrospinal fluid pressure in ocular hypertension. Acta Ophthalmol 2011;89;E142-8.

Jaggi GP, Miller NR, Flammer J, Weinreb RN, Remonda L, Killer HE. Optic nerve sheath diameter in normal-tension glaucoma patients. Br J Ophthalmol 2011 Mar 11. [Epub ahead of print]

NL Wang, XB Xie, DY Yang, et al. “Orbital Cerebrospinal Fluid Space in Glaucoma: The Beijing iCOP Study”. Ophthalmology. 2012 Oct;119(10):2065-2073.

Hou R, Zhang Z, Yang D, Wang H, Chen W, Li Z, Sang J, Liu S, Cao Y, Xie X, Ren R, Zhang Y, Sabel BA, Wang N. Intracranial pressure (ICP) and optic nerve subarachnoid space pressure (ONSP) correlation in the optic nerve chamber: the Beijing Intracranial and Intraocular Pressure (iCOP) study. Brain Res. 2016 Mar 15;1635:201-8.

Yang D, Fu J, Hou R, Liu K, Jonas JB, Wang H, Chen W, Li Z, Sang J, Zhang Z, Liu S, Cao Y, Xie X, Ren R, Lu Q, Weinreb RN, Wang N. Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys. Invest Ophthalmol Vis Sci. 2014 Apr 15; 55(5): 3067-73.

Xie X, Zhang X, Fu J, et al. Noninvasive intracranial pressure estimation by orbital subarachnoid space measurement: the Beijing Intracranial and Intraocular Pressure (iCOP) study[J]. Critical Care, 2013, 17(4): R162.

Berdahl JP, Fleischman D, Zaydlarova J, Stinnett S, Allingham RR, et al. Body mass index has a linear relationship with cerebrospinal fluid pressure. Invest Ophthalmol Vis Sci 2012; 53:1422–1427.

Ren R, Wang N, Zhang X, Tian G, Jonas JB. Cerebrospinal fluid pressure correlated with body mass index. Graefes Arch Clin Exp Ophthalmol 2012; 250:445–446.

Jonas JB, Wang N, Wang YX, You QS, Xie X, Yang D, Xu L. Body height, estimated cerebrospinal fluid pressure and open-angle glaucoma. The Beijing eye study 2011. PLoS One. 2014 Jan 29; 9(1):e86678.

Jonas JB, Nangia V, Wang N, Bhate K, Nangia P, Nangia P, Yang D, Xie X, Panda-Jonas S. Trans-lamina cribrosa pressure difference and open-angle glaucoma. The central India eye and medical study. PLoS One. 2013; 8(12):e82284.


  • There are currently no refbacks.

Copyright (c) 2017 Journal for Modeling in Ophthalmology